She has seen and done it all; from sitting next to Tom Cruise as he jumped on her couch through to giving Dr Phil his shot at the big time. Oprah Winfrey is certainly the queen of all talk show hosts.
But after 25 years interviewing celebrities, politicians, movie stars and everyday people, Oprah has decided to call it quits.
Click on the video player to watch just one of Oprah's most memorable interviews!
It has been reported that her final show will air in September 2011 in her 25th season.
Oprah's production company Harpo Inc revealed in a statement that Oprah would be making an official announcement on the show on Friday.
It is expected that Oprah will also comment on why she has decided to call it a day after 25 years.
The Oprah Winfrey Show is watched by 49 million people in the United States each week and broadcast in more than 145 countries.
Oprah has said that her mission statement for the show was to "use television to transform people's lives, to make viewers see themselves differently and to bring happiness and a sense of fulfillment into every home".
Your say: How do you feel about Oprah finishing her show? Tell us your favourite Oprah moments and interviews.
